MK5 Microarray Data

These are the micro-array results of a differential gene expression microarray experiments and the subsequent analysis steps performed on them. The up/down- regulation ratio was obtained by measuring WT cells against MK5 activated cells. See material and methods for technical information as well as the data usage policy.

Affected Genes

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description	Ratio	Gene Ontology	Regulation	Class	Gene	Accession	Minimum Ratio	Maximum Ratio

Results: HTML CSV LaTeX

Showing element 1 to 50 of 1501 in total

Regulation  : up

description	Ratio	Gene Ontology	Class
ADAM 22 precursor (A disintegrin and metalloproteinase domain 22) (Metalloproteinase-like, disintegrin-like, and cysteine-rich protein 2) (Metalloproteinase-disintegrin ADAM22-3). [Uniprot/SWISSPROT;Acc:Q9P0K1]	1.16499	cell adhesion	biological process
		central nervous system development
		integral to membrane	cellular component
		integrin binding	molecular function
		membrane	cellular component
		metalloendopeptidase activity	molecular function
		negative regulation of cell adhesion	biological process
		protein binding	molecular function
		proteolysis	biological process
		zinc ion binding	molecular function
ADAMTS-19 precursor (EC 3.4.24.-) (A disintegrin and metalloproteinase with thrombospondin motifs 19) (ADAM-TS 19) (ADAM-TS19). [Uniprot/SWISSPROT;Acc:Q8TE59]	2.45875	extracellular matrix	cellular component
		intracellular
		metal ion binding	molecular function
		metalloendopeptidase activity
		metallopeptidase activity
		nucleic acid binding
		peptidase activity
		proteinaceous extracellular matrix	cellular component
		proteolysis	biological process
		zinc ion binding	molecular function
Adiponectin receptor protein 1 (Progestin and adipoQ receptor family member I). [Uniprot/SWISSPROT;Acc:Q96A54]	5.19755	fatty acid oxidation	biological process
		hormone binding	molecular function
		hormone-mediated signaling	biological process
		identical protein binding	molecular function
		integral to membrane	cellular component
		lipid metabolic process	biological process
		membrane	cellular component
		protein heterodimerization activity	molecular function
		receptor activity
Amyloid beta A4 precursor protein-binding family A member 2 (Neuron- specific X11L protein) (Neuronal Munc18-1-interacting protein 2) (Mint-2) (Adapter protein X11beta). [Uniprot/SWISSPROT;Acc:Q99767]	2.49031	nervous system development	biological process
		protein binding	molecular function
		protein transport	biological process
AP-3 complex subunit sigma-1 (Adapter-related protein complex 3 sigma- 1 subunit) (Sigma-adaptin 3a) (AP-3 complex sigma-3A subunit) (Sigma- 3A-adaptin) (Clathrin-associated/assembly/adapter protein, small 3). [Uniprot/SWISSPROT;Acc:Q92572]	4.07995	cytoplasmic vesicle	cellular component
		Golgi apparatus
		insulin receptor signaling pathway	biological process
		intracellular protein transport
		membrane	cellular component
		membrane coat
		membrane coat adaptor complex
		protein binding	molecular function
		protein complex assembly	biological process
		protein transporter activity	molecular function
		transport	biological process
		transport vesicle	cellular component
		transporter activity	molecular function
		vesicle-mediated transport	biological process
Armadillo repeat-containing X-linked protein 3 (Protein ALEX3) (ARM protein lost in epithelial cancers on chromosome X 3). [Uniprot/SWISSPROT;Acc:Q9UH62]	1.63713	binding	molecular function
		integral to membrane	cellular component
		membrane
Ataxin-7 (Spinocerebellar ataxia type 7 protein). [Uniprot/SWISSPROT;Acc:O15265]	2.29381	cell death	biological process

Legend:
- The Ratio specifies how much this gene is up/down regulated. When up- or down-regulated must this value respectively be multiplied/divided to obtain the MK5 on concentration based on the MK5 off concentration.
- The Regulation specifies how this gene is affected when going from the MK5 off cells to the MK5 on cells.
- The Class refers to the ontology category, which can be molecular_function, biological_process or cellular_component.
- The Gene Ontology terms as linked to the specific gene.
- Gene is the ensembl human gene identifier measured by 1 or more probes on the microarray
- Accession is the GO accession key.
- Minimum Ratio is the lowest expected regulation ratio based on the replicate slides and a 95% symmetric confidence interval.
- Maximum Ratio is the highest expected regulation ratio based on the replicate slides and a 95% symmetric confidence interval.