MK5 Microarray Data

These are the micro-array results of a differential gene expression microarray experiments and the subsequent analysis steps performed on them. The up/down- regulation ratio was obtained by measuring WT cells against MK5 activated cells. See material and methods for technical information as well as the data usage policy.

Affected Genes

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Regulation	Class	Ratio	Gene Ontology	Gene	description	Accession	Minimum Ratio	Maximum Ratio

Results: HTML CSV LaTeX

Showing element 1 to 50 of 2667 in total

Regulation  : down
Class  : biological process

Ratio	Gene Ontology	description
1.11083	neurotransmitter transport	Sodium- and chloride-dependent transporter XTRP3 (Solute carrier family 6 member 20) (Neurotransmitter transporter rB21A homolog). [Uniprot/SWISSPROT;Acc:Q9NP91]
1.11956	retrograde vesicle-mediated transport, Golgi to ER	Protein RER1. [Uniprot/SWISSPROT;Acc:O15258]
1.1243	regulation of transcription, DNA-dependent	Zinc finger protein basonuclin-2. [Uniprot/SWISSPROT;Acc:Q6ZN30]
	transcription
1.13541	blood coagulation	Protein kinase C-binding protein NELL2 precursor (NEL-like protein 2) (Nel-related protein 2). [Uniprot/SWISSPROT;Acc:Q99435]
	cell adhesion
	regulation of growth
1.14311	negative regulation of protein kinase activity	14-3-3 protein gamma (Protein kinase C inhibitor protein 1) (KCIP-1). [Uniprot/SWISSPROT;Acc:P61981]
	protein targeting
	regulation of neuron differentiation
	regulation of signal transduction
	regulation of synaptic plasticity
1.1611	electron transport	Guanylin precursor (Guanylate cyclase activator 2A) (Guanylate cyclase-activating protein 1) (Gap-I) [Contains: HMW-guanylin; Guanylin]. [Uniprot/SWISSPROT;Acc:Q02747]
	signal transduction
1.18096	anagen	Prostaglandin G/H synthase 2 precursor (EC 1.14.99.1) (Cyclooxygenase- 2) (COX-2) (Prostaglandin-endoperoxide synthase 2) (Prostaglandin H2 synthase 2) (PGH synthase 2) (PGHS-2) (PHS II). [Uniprot/SWISSPROT;Acc:P35354]
	blood pressure regulation
	cell motility
	cyclooxygenase pathway
	electron transport
	fatty acid biosynthetic process
	negative regulation of cell proliferation
	regulation of inflammatory response
	regulation of progression through cell cycle
	response to oxidative stress
1.18821	cytokine and chemokine mediated signaling pathway	Cytokine receptor common beta chain precursor (GM-CSF/IL-3/IL-5 receptor common beta-chain) (CD131 antigen) (CDw131). [Uniprot/SWISSPROT;Acc:P32927]
	respiratory gaseous exchange
	signal transduction
1.19134	cell-cell signaling	Proprotein convertase subtilisin/kexin type 6 precursor (EC 3.4.21.-) (Paired basic amino acid cleaving enzyme 4) (Subtilisin/kexin-like protease PACE4) (Subtilisin-like proprotein convertase 4) (SPC4). [Uniprot/SWISSPROT;Acc:P29122]
	determination of left/right symmetry
	proteolysis
	zygotic determination of anterior/posterior axis, embryo
1.19212	hormone biosynthetic process	Thyroglobulin precursor. [Uniprot/SWISSPROT;Acc:P01266]
	signal transduction
	thyroid hormone generation
1.20481	biological_process	Neurosecretory protein VGF precursor. [Uniprot/SWISSPROT;Acc:O15240]
	generation of precursor metabolites and energy
	ovarian follicle development
	sexual reproduction
1.20619	ATP hydrolysis coupled proton transport	Sodium/potassium-transporting ATPase subunit alpha-4 (EC 3.6.3.9) (Sodium pump subunit alpha-4) (Na(+)/K(+) ATPase alpha-4 subunit). [Uniprot/SWISSPROT;Acc:Q13733]
	cation transport
	hydrogen ion homeostasis
	metabolic process
	monovalent inorganic cation transport
	potassium ion transport
	proton transport
	sodium ion transport
	sperm motility
	transport
1.20924	alcohol metabolic process	Aldehyde dehydrogenase 1A3 (EC 1.2.1.5) (Aldehyde dehydrogenase 6) (Retinaldehyde dehydrogenase 3) (RALDH-3). [Uniprot/SWISSPROT;Acc:P47895]
	embryonic eye morphogenesis

Legend:
- The Ratio specifies how much this gene is up/down regulated. When up- or down-regulated must this value respectively be multiplied/divided to obtain the MK5 on concentration based on the MK5 off concentration.
- The Regulation specifies how this gene is affected when going from the MK5 off cells to the MK5 on cells.
- The Class refers to the ontology category, which can be molecular_function, biological_process or cellular_component.
- The Gene Ontology terms as linked to the specific gene.
- Gene is the ensembl human gene identifier measured by 1 or more probes on the microarray
- Accession is the GO accession key.
- Minimum Ratio is the lowest expected regulation ratio based on the replicate slides and a 95% symmetric confidence interval.
- Maximum Ratio is the highest expected regulation ratio based on the replicate slides and a 95% symmetric confidence interval.