MK5 Microarray Data

These are the micro-array results of a differential gene expression microarray experiments and the subsequent analysis steps performed on them. The up/down- regulation ratio was obtained by measuring WT cells against MK5 activated cells. See material and methods for technical information as well as the data usage policy.

Affected Genes

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description	Regulation	Gene Ontology	Accession	Class	Gene	Ratio	Maximum Ratio	Minimum Ratio

Results: HTML CSV LaTeX

Showing element 1 to 50 of 2667 in total

description	Regulation	Gene Ontology	Class	Ratio
14-3-3 protein gamma (Protein kinase C inhibitor protein 1) (KCIP-1). [Uniprot/SWISSPROT;Acc:P61981]	down	cytoplasm	cellular component	1.14311
		insulin-like growth factor receptor binding	molecular function
		negative regulation of protein kinase activity	biological process
		protein domain specific binding	molecular function
		protein kinase C binding
		protein kinase C inhibitor activity
		protein targeting	biological process
		regulation of neuron differentiation
		regulation of signal transduction
		regulation of synaptic plasticity
28S ribosomal protein S35, mitochondrial precursor (S35mt) (MRP-S35) (Mitochondrial ribosomal protein S28) (MRP-S28). [Uniprot/SWISSPROT;Acc:P82673]		DNA damage response, detection of DNA damage		2.61135
		mitochondrial small ribosomal subunit	cellular component
		mitochondrion
		peptide biosynthetic process	biological process
		ribonucleoprotein complex	cellular component
39S ribosomal protein L15, mitochondrial precursor (L15mt) (MRP-L15). [Uniprot/SWISSPROT;Acc:Q9P015]		intracellular		2.16131
		large ribosomal subunit
		mitochondrion
		ribosome
		structural constituent of ribosome	molecular function
		translation	biological process
40S ribosomal protein S2 (S4) (LLRep3 protein). [Uniprot/SWISSPROT;Acc:P15880]		cytosolic small ribosomal subunit (sensu Eukaryota)	cellular component	2.45383
		intracellular
		ribosome
		RNA binding	molecular function
		small ribosomal subunit	cellular component
		structural constituent of ribosome	molecular function
		translation	biological process
ADAM 12 precursor (EC 3.4.24.-) (A disintegrin and metalloproteinase domain 12) (Meltrin alpha). [Uniprot/SWISSPROT;Acc:O43184]		cell adhesion		1.76994
		integral to membrane	cellular component
		metal ion binding	molecular function
		metalloendopeptidase activity
		metallopeptidase activity
		myoblast fusion	biological process
		plasma membrane	cellular component
		protein binding	molecular function
		proteolysis	biological process
		zinc ion binding	molecular function
ADAM 22 precursor (A disintegrin and metalloproteinase domain 22) (Metalloproteinase-like, disintegrin-like, and cysteine-rich protein 2) (Metalloproteinase-disintegrin ADAM22-3). [Uniprot/SWISSPROT;Acc:Q9P0K1]	up	cell adhesion	biological process	1.16499
		central nervous system development
		integral to membrane	cellular component
		integrin binding	molecular function
		membrane	cellular component
		metalloendopeptidase activity	molecular function
		negative regulation of cell adhesion	biological process
		protein binding	molecular function
		proteolysis	biological process
		zinc ion binding	molecular function
ADAM metallopeptidase with thrombospondin type 1 motif, 7 preproprotein [RefSeq_peptide;Acc:NP_055087]	down	extracellular matrix	cellular component	1.28805
		metal ion binding	molecular function

Legend:
- The Ratio specifies how much this gene is up/down regulated. When up- or down-regulated must this value respectively be multiplied/divided to obtain the MK5 on concentration based on the MK5 off concentration.
- The Regulation specifies how this gene is affected when going from the MK5 off cells to the MK5 on cells.
- The Class refers to the ontology category, which can be molecular_function, biological_process or cellular_component.
- The Gene Ontology terms as linked to the specific gene.
- Gene is the ensembl human gene identifier measured by 1 or more probes on the microarray
- Accession is the GO accession key.
- Minimum Ratio is the lowest expected regulation ratio based on the replicate slides and a 95% symmetric confidence interval.
- Maximum Ratio is the highest expected regulation ratio based on the replicate slides and a 95% symmetric confidence interval.