Scientific

MK5 Microarray Data

Affected Genes - Ontology Breakdown - Gene Enrichment - Proteome Analysis

These are the micro-array results of a differential gene expression microarray experiments and the subsequent analysis steps performed on them. The up/down- regulation ratio was obtained by measuring WT cells against MK5 activated cells. See material and methods for technical information as well as the data usage policy.

Affected Genes


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Regulation Gene Ontology Accession description Minimum Ratio Ratio Gene Class Maximum Ratio
Results: HTML CSV LaTeX Showing element 1 to 50 of 2667 in total
Regulation  : down
Gene Ontology
description
Ratio
Class
1-phosphatidylinositol-3-kinase activity Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit gamma isoform (EC 2.7.1.153) (PI3-kinase p110 subunit gamma) (PtdIns-3- kinase subunit p110) (PI3K) (PI3Kgamma) (p120-PI3K). [Uniprot/SWISSPROT;Acc:P48736] 5.23046 molecular function
3-chloroallyl aldehyde dehydrogenase activity Aldehyde dehydrogenase 1A3 (EC 1.2.1.5) (Aldehyde dehydrogenase 6) (Retinaldehyde dehydrogenase 3) (RALDH-3). [Uniprot/SWISSPROT;Acc:P47895] 1.20924
7S RNA binding Protein CWC15 homolog. [Uniprot/SWISSPROT;Acc:Q9P013] 1.25205
acetyltransferase activity Arylamine N-acetyltransferase 1 (EC 2.3.1.5) (Arylamide acetylase 1) (Monomorphic arylamine N-acetyltransferase) (MNAT) (N- acetyltransferase type 1) (NAT-1). [Uniprot/SWISSPROT;Acc:P18440] 3.00923
Arylamine N-acetyltransferase 2 (EC 2.3.1.5) (Arylamide acetylase 2) (Polymorphic arylamine N-acetyltransferase) (PNAT) (N- acetyltransferase type 2) (NAT-2). [Uniprot/SWISSPROT;Acc:P11245] 4.69231
actin binding Myosin-15 (Myosin heavy chain 15). [Uniprot/SWISSPROT;Acc:Q9Y2K3] 1.24114
Myosin-If (Myosin-Ie). [Uniprot/SWISSPROT;Acc:O00160] 1.23668
WAS protein homology region 2 domain containing 1 [RefSeq_peptide;Acc:NP_001073904] 1.54676
actin cytoskeleton cellular component
alcohol metabolic process Aldehyde dehydrogenase 1A3 (EC 1.2.1.5) (Aldehyde dehydrogenase 6) (Retinaldehyde dehydrogenase 3) (RALDH-3). [Uniprot/SWISSPROT;Acc:P47895] 1.20924 biological process
Aldehyde dehydrogenase, mitochondrial precursor (EC 1.2.1.3) (ALDH class 2) (ALDHI) (ALDH-E2). [Uniprot/SWISSPROT;Acc:P05091] 4.40797
aldehyde dehydrogenase (NAD) activity molecular function
aldehyde dehydrogenase [NAD(P)+] activity Aldehyde dehydrogenase 1A3 (EC 1.2.1.5) (Aldehyde dehydrogenase 6) (Retinaldehyde dehydrogenase 3) (RALDH-3). [Uniprot/SWISSPROT;Acc:P47895] 1.20924
Aldehyde dehydrogenase, mitochondrial precursor (EC 1.2.1.3) (ALDH class 2) (ALDHI) (ALDH-E2). [Uniprot/SWISSPROT;Acc:P05091] 4.40797
amino acid metabolic process Cystinosin. [Uniprot/SWISSPROT;Acc:O60931] 1.75846 biological process
Sodium- and chloride-dependent neutral and basic amino acid transporter B(0+) (Amino acid transporter ATB0+) (Solute carrier family 6 member 14). [Uniprot/SWISSPROT;Acc:Q9UN76] 1.40552
amino acid transport
amino acid transporter activity molecular function
aminoacyl-tRNA ligase activity Threonyl-tRNA synthetase, mitochondrial precursor (EC 6.1.1.3) (Threonine--tRNA ligase) (ThrRS) (Threonyl-tRNA synthetase-like 1). [Uniprot/SWISSPROT;Acc:Q9BW92] 2.25955
aminopeptidase activity leukocyte-derived arginine aminopeptidase [RefSeq_peptide;Acc:NP_071745] 1.76583
anagen Prostaglandin G/H synthase 2 precursor (EC 1.14.99.1) (Cyclooxygenase- 2) (COX-2) (Prostaglandin-endoperoxide synthase 2) (Prostaglandin H2 synthase 2) (PGH synthase 2) (PGHS-2) (PHS II). [Uniprot/SWISSPROT;Acc:P35354] 1.18096 biological process
anatomical structure morphogenesis Homeobox protein Hox-D3 (Hox-4A). [Uniprot/SWISSPROT;Acc:P31249] 1.27461
anion exchanger activity Anion exchange protein 3 (Neuronal band 3-like protein) (Solute carrier family 4 member 3) (Cardiac/brain band 3-like protein) (CAE3/BAE3). [Uniprot/SWISSPROT;Acc:P48751] 2.88235 molecular function
anion transport biological process
antigen processing and presentation of endogenous peptide antigen via MHC class I leukocyte-derived arginine aminopeptidase [RefSeq_peptide;Acc:NP_071745] 1.76583
antiporter activity Anion exchange protein 3 (Neuronal band 3-like protein) (Solute carrier family 4 member 3) (Cardiac/brain band 3-like protein) (CAE3/BAE3). [Uniprot/SWISSPROT;Acc:P48751] 2.88235 molecular function
AP-1 adaptor complex Low density lipoprotein receptor adapter protein 1 (Autosomal recessive hypercholesterolemia protein). [Uniprot/SWISSPROT;Acc:Q5SW96] 1.30207 cellular component
AP-2 adaptor complex
apoptosis Calsenilin (Kv channel-interacting protein 3) (KChIP3) (A-type potassium channel modulatory protein 3) (DRE-antagonist modulator) (DREAM). [Uniprot/SWISSPROT;Acc:Q9Y2W7] 3.27919 biological process
Engulfment and cell motility protein 2 (CED-12 homolog A) (hCED-12A). [Uniprot/SWISSPROT;Acc:Q96JJ3] 4.50619
Protein Jade-1 (PHD finger protein 17). [Uniprot/SWISSPROT;Acc:Q6IE81] 6.3909
apoptotic program Bcl-2-interacting killer (Apoptosis inducer NBK) (BP4) (BIP1). [Uniprot/SWISSPROT;Acc:Q13323] 1.21871
arylamine N-acetyltransferase activity Arylamine N-acetyltransferase 1 (EC 2.3.1.5) (Arylamide acetylase 1) (Monomorphic arylamine N-acetyltransferase) (MNAT) (N- acetyltransferase type 1) (NAT-1). [Uniprot/SWISSPROT;Acc:P18440] 3.00923 molecular function
Arylamine N-acetyltransferase 2 (EC 2.3.1.5) (Arylamide acetylase 2) (Polymorphic arylamine N-acetyltransferase) (PNAT) (N- acetyltransferase type 2) (NAT-2). [Uniprot/SWISSPROT;Acc:P11245] 4.69231
ATP binding Antigen KI-67. [Uniprot/SWISSPROT;Acc:P46013] 1.73211
ATP-binding domain 1 family member B. [Uniprot/SWISSPROT;Acc:Q9H9Y4] 3.06659
Canalicular multispecific organic anion transporter 2 (ATP-binding cassette sub-family C member 3) (Multidrug resistance-associated protein 3) (Multi-specific organic anion transporter-D) (MOAT-D). [Uniprot/SWISSPROT;Acc:O15438] 1.30802
Chromodomain-helicase-DNA-binding protein 6 (EC 3.6.1.-) (ATP- dependent helicase CHD6) (CHD-6) (Radiation-induced gene B protein). [Uniprot/SWISSPROT;Acc:Q8TD26] 1.60746
Contactin-3 precursor (Brain-derived immunoglobulin superfamily protein 1) (BIG-1) (Plasmacytoma-associated neuronal glycoprotein). [Uniprot/SWISSPROT;Acc:Q9P232] 3.99682
Fibroblast growth factor receptor 3 precursor (EC 2.7.10.1) (FGFR-3) (CD333 antigen). [Uniprot/SWISSPROT;Acc:P22607] 1.30142
Myosin-15 (Myosin heavy chain 15). [Uniprot/SWISSPROT;Acc:Q9Y2K3] 1.24114
Myosin-If (Myosin-Ie). [Uniprot/SWISSPROT;Acc:O00160] 1.23668
Nuclear pore complex protein Nup153 (Nucleoporin Nup153) (153 kDa nucleoporin). [Uniprot/SWISSPROT;Acc:P49790] 1.48389
Putative DNA helicase INO80 complex homolog 1 (EC 3.6.1.-) (hINO80). [Uniprot/SWISSPROT;Acc:Q9ULG1] 1.81557
Serine/threonine-protein kinase VRK3 (EC 2.7.11.1) (Vaccinia-related kinase 3). [Uniprot/SWISSPROT;Acc:Q8IV63] 4.14557
Sodium/potassium-transporting ATPase subunit alpha-4 (EC 3.6.3.9) (Sodium pump subunit alpha-4) (Na(+)/K(+) ATPase alpha-4 subunit). [Uniprot/SWISSPROT;Acc:Q13733] 1.20619
Threonyl-tRNA synthetase, mitochondrial precursor (EC 6.1.1.3) (Threonine--tRNA ligase) (ThrRS) (Threonyl-tRNA synthetase-like 1). [Uniprot/SWISSPROT;Acc:Q9BW92] 2.25955
Ubiquitin-conjugating enzyme E2 Q2 (EC 6.3.2.19) (Ubiquitin-protein ligase Q2) (Ubiquitin carrier protein Q2). [Uniprot/SWISSPROT;Acc:Q8WVN8] 1.59763
Wee1-like protein kinase (EC 2.7.10.2) (Wee1A kinase) (WEE1hu). [Uniprot/SWISSPROT;Acc:P30291] 1.48363
ATP hydrolysis coupled proton transport Sodium/potassium-transporting ATPase subunit alpha-4 (EC 3.6.3.9) (Sodium pump subunit alpha-4) (Na(+)/K(+) ATPase alpha-4 subunit). [Uniprot/SWISSPROT;Acc:Q13733] 1.20619 biological process

Legend:
- The Ratio specifies how much this gene is up/down regulated. When up- or down-regulated must this value respectively be multiplied/divided to obtain the MK5 on concentration based on the MK5 off concentration.
- The Regulation specifies how this gene is affected when going from the MK5 off cells to the MK5 on cells.
- The Class refers to the ontology category, which can be molecular_function, biological_process or cellular_component.
- The Gene Ontology terms as linked to the specific gene.
- Gene is the ensembl human gene identifier measured by 1 or more probes on the microarray
- Accession is the GO accession key.
- Minimum Ratio is the lowest expected regulation ratio based on the replicate slides and a 95% symmetric confidence interval.
- Maximum Ratio is the highest expected regulation ratio based on the replicate slides and a 95% symmetric confidence interval.
- http://analysis.yellowcouch.org/