MK5 Microarray Data

These are the micro-array results of a differential gene expression microarray experiments and the subsequent analysis steps performed on them. The up/down- regulation ratio was obtained by measuring WT cells against MK5 activated cells. See material and methods for technical information as well as the data usage policy.

Affected Genes

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Ratio	Regulation	description	Class	Gene Ontology	Gene	Accession	Minimum Ratio	Maximum Ratio

Results: HTML CSV LaTeX

Showing element 2401 to 2450 of 2667 in total

Ratio	Regulation	description	Class	Gene Ontology
4.05743	up	Clarin-1 (Usher syndrome type-3 protein). [Uniprot/SWISSPROT;Acc:P58418]	cellular component	membrane
4.07995		AP-3 complex subunit sigma-1 (Adapter-related protein complex 3 sigma- 1 subunit) (Sigma-adaptin 3a) (AP-3 complex sigma-3A subunit) (Sigma- 3A-adaptin) (Clathrin-associated/assembly/adapter protein, small 3). [Uniprot/SWISSPROT;Acc:Q92572]	biological process	insulin receptor signaling pathway
				intracellular protein transport
				protein complex assembly
				transport
				vesicle-mediated transport
			cellular component	cytoplasmic vesicle
				Golgi apparatus
				membrane
				membrane coat
				membrane coat adaptor complex
				transport vesicle
			molecular function	protein binding
				protein transporter activity
				transporter activity
4.1026		Uncharacterized protein C2orf29. [Uniprot/SWISSPROT;Acc:Q9UKZ1]	biological process	cell proliferation
			cellular component	cellular_component
			molecular function	molecular_function
4.14054		Protein odd-skipped-related 2. [Uniprot/SWISSPROT;Acc:Q8N2R0]	biological process	embryonic skeletal morphogenesis
				positive regulation of cell proliferation
			cellular component	intracellular
				nucleus
			molecular function	metal ion binding
				nucleic acid binding
				zinc ion binding
4.14557	down	Serine/threonine-protein kinase VRK3 (EC 2.7.11.1) (Vaccinia-related kinase 3). [Uniprot/SWISSPROT;Acc:Q8IV63]	biological process	protein amino acid phosphorylation
			cellular component	nucleus
			molecular function	ATP binding
				nucleotide binding
				protein kinase activity
				protein serine/threonine kinase activity
				transferase activity
4.21401		Uncharacterized protein C17orf56. [Uniprot/SWISSPROT;Acc:Q96N21]	cellular component	membrane
4.22898	up	Enoyl-CoA hydratase domain-containing protein 1. [Uniprot/SWISSPROT;Acc:Q9NTX5]	biological process	metabolic process
			molecular function	catalytic activity
4.40598		GMP reductase 1 (EC 1.7.1.7) (Guanosine 5'-monophosphate oxidoreductase 1) (Guanosine monophosphate reductase 1). [Uniprot/SWISSPROT;Acc:P36959]	biological process	metabolic process
				nucleotide metabolic process
				response to cold
			molecular function	catalytic activity
				GMP reductase activity
				metal ion binding
				oxidoreductase activity
				potassium ion binding
4.40797	down	Aldehyde dehydrogenase, mitochondrial precursor (EC 1.2.1.3) (ALDH class 2) (ALDHI) (ALDH-E2). [Uniprot/SWISSPROT;Acc:P05091]	biological process	alcohol metabolic process
				carbohydrate metabolic process
				metabolic process
				neuropeptide signaling pathway
			cellular component	mitochondrion
			molecular function	aldehyde dehydrogenase (NAD) activity
				aldehyde dehydrogenase [NAD(P)+] activity

Legend:
- The Ratio specifies how much this gene is up/down regulated. When up- or down-regulated must this value respectively be multiplied/divided to obtain the MK5 on concentration based on the MK5 off concentration.
- The Regulation specifies how this gene is affected when going from the MK5 off cells to the MK5 on cells.
- The Class refers to the ontology category, which can be molecular_function, biological_process or cellular_component.
- The Gene Ontology terms as linked to the specific gene.
- Gene is the ensembl human gene identifier measured by 1 or more probes on the microarray
- Accession is the GO accession key.
- Minimum Ratio is the lowest expected regulation ratio based on the replicate slides and a 95% symmetric confidence interval.
- Maximum Ratio is the highest expected regulation ratio based on the replicate slides and a 95% symmetric confidence interval.