MK5 Microarray Data

These are the micro-array results of a differential gene expression microarray experiments and the subsequent analysis steps performed on them. The up/down- regulation ratio was obtained by measuring WT cells against MK5 activated cells. See material and methods for technical information as well as the data usage policy.

Proteome Analysis

Below the proteome analysis is presented. The analysis methods are presented in the paper Propagating Differential Gene Expression in Protein Interaction Networks. If you are interested in the most reliable results choose the

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Rank	description	green	Gene	Network Comparison Type	Value Type	Filtered	Interaction Map	red	network_comparison

Results: HTML CSV LaTeX

Showing element 1 to 50 of 77072 in total

Rank	description	green	Network Comparison Type	Value Type	Filtered	Interaction Map	red	network_comparison
1	adp-ribosylation factor gtpase-activating protein 3 (arf gap 3). [swissprot;acc:q9np61]	15915	Divided	Ranked	0	High confidence	4294	3.70633
	ba508n22.1 (hspc025) (fragment). [sptrembl;acc:q9hcw5]	60.0707	Subtracted	Rooted			9.20014	50.8706
						Low confidence
		6410		Measured		High confidence	85	6325
						Low confidence
	cab2. [refseq;acc:nm_033419]	7.16592	Divided	Squared		High confidence	0.00001	716592
	carboxypeptidase d precursor (ec 3.4.17.-) (gp180). [swissprot;acc:o75976]	32		Ranked	1	Low confidence	16	2
		32028.5	Subtracted	Measured			40899	8870.5
		242799		Squared			395912	153113
	homeobox protein hlx1 (homeobox protein hb24). [swissprot;acc:q14774]	322		Ranked		High confidence	215	107
	homeobox protein hox-c4 (hox-3e) (cp19). [swissprot;acc:p09017]	1.87479	Divided	Squared	0	Low confidence	0.00001	187479
	lysosome-associated membrane glycoprotein 1 precursor (lamp-1) (cd107a antigen). [swissprot;acc:p11279]	23.3131		Rooted	1		48.9847	2.10117
			Subtracted					25.6716
		69.9153	Divided	Squared			1362.75	19.4914
		330	Subtracted	Ranked			223	107
		543.5	Divided	Measured			2399.5	4.4149
	mannosyl-oligosaccharide 1,2-alpha-mannosidase ib (ec 3.2.1.113) (processing alpha-1,2-mannosidase ib) (alpha-1,2-mannosidase ib) (mannosidase alpha class 1a member 2). [swissprot;acc:o60476]	33356.5	Subtracted			High confidence	41482.5	8126
	mitochondrial 28s ribosomal protein s32 (s32mt) (mrp-s32) (ptd007) (hspc204). [swissprot;acc:q9y6g3]	0.00001	Divided		0		364	36400000
						Low confidence
				Rooted		High confidence	19.0788	1907880
						Low confidence
		21883	Subtracted	Ranked		High confidence	8906	12977
						Low confidence
	mln 64 protein (star-related lipid transfer protein 3) (stard3) (start domain-containing protein 3) (cab1 protein). [swissprot;acc:q14849]	14977	Divided				5865	2.55362
	nuclear dna-binding protein; small unique nuclear receptor corepressor; c1d dna-binding protein. [refseq;acc:nm_006333]	160184	Subtracted	Squared		High confidence	232467	72283
						Low confidence
	putative glialblastoma cell differentiation-related; putative glialblastoma cell differentiation-related protein. [refseq;acc:nm_016172]	24	Divided	Ranked	1	High confidence	10	2.4
		322755	Subtracted	Squared			468498	145743
	rad50-interacting protein 1. [refseq;acc:nm_021930]	48.9336	Divided	Rooted			21.225	2.30547
			Subtracted					27.7086
		1357.07	Divided	Squared			48.0356	28.2513
		2394.5		Measured			450.5	5.31521
2	28s ribosomal protein s17, mitochondrial precursor (mrp-s17) (hspc011). [swissprot;acc:q9y2r5]	28492	Subtracted			Low confidence	21185	7307
	adp-ribosylation factor gtpase-activating protein 3 (arf gap 3). [swissprot;acc:q9np61]	15915		Ranked	0	High confidence	4294	11621
	bestrophin (vitelliform macular dystrophy protein) (tu15b). [swissprot;acc:o76090]	475119		Squared	1	Low confidence	333556	141563
	cab2. [refseq;acc:nm_033419]	174	Divided	Measured	0	High confidence	0.00001	17400000
	cell division protein kinase 4 (ec 2.7.1.37) (cyclin-dependent kinase 4) (psk-j3). [swissprot;acc:p11802]	23.3131		Rooted	1	Low confidence	48.9847	2.10117
			Subtracted					25.6716
		69.9153	Divided	Squared			1362.75	19.4914
		330	Subtracted	Ranked			223	107
		543.5	Divided	Measured			2399.5	4.4149
	cytohesin 1 (sec7 homolog b2-1). [swissprot;acc:q15438]	33356.5	Subtracted			High confidence	41482.5	8126
	hbs1-like. [refseq;acc:nm_006620]	322		Ranked			215	107
	histone h4. [swissprot;acc:p02304]	345123		Squared	0		273623	71500
	homeobox protein hox-c4 (hox-3e) (cp19). [swissprot;acc:p09017]	9.43398	Divided	Rooted		Low confidence	0.00001	943398
		89		Measured				8900000
	homeobox protein hox-c6 (hox-3c) (hho.c8) (cp25). [swissprot;acc:p09630]	1.87479		Squared				187479
	lipopolysaccharide-responsive and beige-like anchor protein (cdc4-like protein) (beige-like protein). [swissprot;acc:p50851]	60.0707	Subtracted	Rooted		High confidence	9.20014	50.8706
		6410		Measured			85	6325
	lysosome-associated membrane glycoprotein 1 precursor (lamp-1) (cd107a antigen). [swissprot;acc:p11279]	330	Divided	Ranked	1	Low confidence	223	1.47982

Legend:
- Rank is the rank after comparing the two networks
- Gene is the ensembl human gene identifier measured by 1 or more probes on the microarray
- Value Type describes how the microarray measurement was processed. Ranked indicates that we sorted all measurements and use the rank as red and green value. Measured is the normal measurement. Squared and Rooted are the square and square root respecitcely. This might be valueable to compensate for non linear light distributions.
- Network Comparison Type describes whether we divided the red and green types or whether we sutractcted them
- Interaction Map specifies whether we used only the hig hconfidence protein-protein interactions or also included the low confidence interactions.
- Filtered specifies whether we only included the high confidence microarry measurements or not.