MK5 Microarray Data

These are the micro-array results of a differential gene expression microarray experiments and the subsequent analysis steps performed on them. The up/down- regulation ratio was obtained by measuring WT cells against MK5 activated cells. See material and methods for technical information as well as the data usage policy.

MK5 Proteome Analysis - Divided Values

Type II network, divided values. Interestingly most of the proteins in the first 100 positions in this table would occur in the divided ranks table between position 100 and 200, indicating a difference in emphasis between the two simulations but not in the overall function. The fully annotated table, include Ensembl gene identifiers and network values can be found in the supplementary data.

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Gene	Value Type	Rank	description	Network Comparison Type	Interaction Map	Filtered	network_comparison	red	green

Results: HTML CSV LaTeX

Showing element 851 to 900 of 19268 in total

Value Type  : Measured

Rank	description	Network Comparison Type	Interaction Map	Filtered	network_comparison	red	green
107	60s ribosomal protein l7. [swissprot;acc:p18124]	Subtracted	High confidence	0	290.8	1915.27	2206.07
	isoleucyl-trna synthetase, cytoplasmic (ec 6.1.1.5) (isoleucine--trna ligase) (ilers) (irs). [swissprot;acc:p41252]	Divided			1.4467	326.677	472.605
	septin 1 (larp) (serologically defined breast cancer antigen ny-br- 24). [swissprot;acc:q8wyj6]	Subtracted		1	2551.5	14229.2	16780.7
	sh3 domain-binding glutamic acid-rich-like protein 2 (fovea-associated sh3 domain binding protein). [swissprot;acc:q9ujc5]	Divided	Low confidence	0	1.42539	160	112.25
	tumor protein p53 inducible protein 3; quinone oxidoreductase homolog; p53-induced gene 3 protein. [refseq;acc:nm_004881]			1	1.09746	11371	12479.2
	zinc finger protein 415. [refseq;acc:nm_018355]	Subtracted		0	382.97	2352.12	1969.15
108	basic proline-rich peptide p-e (ib-9). [swissprot;acc:p02811]	Divided	High confidence		1.44178	292	421
	cytochrome p450 27, mitochondrial precursor (ec 1.14.-.-) (cytochrome p-450c27/25) (sterol 26-hydroxylase) (sterol 27-hydroxylase) (vitamin d(3) 25-hydroxylase) (5-beta-cholestane-3-alpha,7-alpha,12-alpha-triol 27-hydroxylase). [swissprot;acc:q02318]	Subtracted	Low confidence	1	882.45	3035.43	3917.88
	filamin b, beta (actin binding protein 278); beta filamin; filamin 1 (actin-binding protein-280)-like; filamin b, beta (actin-binding protein-278); filamin b, beta. [refseq;acc:nm_001457]	Divided	High confidence		1.35116	4366.44	5899.76
	microtubule-associated protein, rp/eb family, member 2; t-cell activation protein, eb1 family; apc-binding protein eb1. [refseq;acc:nm_014268]	Subtracted		0	290.131	482.426	192.295
	nanos (fragment). [sptrembl;acc:q8wy41]	Divided	Low confidence		1.41306	338.761	478.69
	ral guanine nucleotide dissociation stimulator (ralgef) (ralgds). [swissprot;acc:q12967]	Subtracted	High confidence	1	2498.4	14021.4	11523
	septin 1 (larp) (serologically defined breast cancer antigen ny-br- 24). [swissprot;acc:q8wyj6]	Divided	Low confidence		1.09685	10499	11515.8
	zinc finger protein 10 (zinc finger protein kox1) (fragment). [swissprot;acc:p21506]	Subtracted		0	382.97	2352.16	1969.19
109	44050 protein. [refseq;acc:nm_178832]		High confidence	1	2496.7	17385.9	14889.2
	cytochrome p450 24a1, mitochondrial precursor (ec 1.14.-.-) (p450- cc24) (vitamin d(3) 24-hydroxylase) (1,25-dihydroxyvitamin d(3) 24- hydroxylase) (24-ohase). [swissprot;acc:q07973]		Low confidence		870.14	3126.88	3997.02
	dead-box protein abstrakt homolog. [swissprot;acc:q9ujv9]	Divided	High confidence	0	1.44	100	144
	rev1-like; rev1 protein; rev1 (yeast homolog)- like. [refseq;acc:nm_016316]			1	1.35116	4366.44	5899.76
	vacuolar atp synthase subunit g 2 (ec 3.6.3.14) (v-atpase g subunit 2) (vacuolar proton pump g subunit 2) (v-atpase 13 kda subunit 2). [swissprot;acc:o95670]	Subtracted		0	288.164	934.726	1222.89
	vacuolar protein sorting 33b (hvps33b). [swissprot;acc:q9h267]	Divided	Low confidence	1	1.0966	7354.65	8065.08
	zinc finger protein 225. [swissprot;acc:q9uk10]	Subtracted		0	382.97	2352.16	1969.19
	zinc finger protein-like 1; zinc-finger protein in men1 region. [refseq;acc:nm_006782]	Divided			1.41039	385	543
110	dj681n20.2 (novel protein similar to ferritin, light polypeptide (ftl)). [sptrembl;acc:q9byw6]	Subtracted	High confidence		288	528.5	816.5
	enigma protein; lim domain protein. [refseq;acc:nm_005451]	Divided	Low confidence		1.38222	967.877	1337.82
	high-mobility group 20b; sox-like transcriptional factor; swi/snf-related matrix-associated actin-dependent regulator of chromatin subfamily e, member 1-related. [refseq;acc:nm_006339]			1	1.09572	7206.99	7896.81
	methylenetetrahydrofolate reductase (ec 1.5.1.20). [swissprot;acc:p42898]	Subtracted			868	10452.8	11320.8
	nuclear inhibitor of protein phosphatase-1 (nipp-1) (protein phosphatase 1, regulatory inhibitor subunit 8) [includes: activator of rna decay (ec 3.1.4.-) (ard-1)]. [swissprot;acc:q12972]		High confidence		2496.7	17385.9	14889.2
	protein arginine n-methyltransferase 1 (ec 2.1.1.-) (interferon receptor 1-bound protein 4). [swissprot;acc:q99873]	Divided			1.35116	4366.44	5899.76
	spectrin alpha chain, brain (spectrin, non-erythroid alpha chain) (alpha-ii spectrin) (fodrin alpha chain). [swissprot;acc:q13813]			0	1.43863	1833	2637
	zinc finger protein 256 (bone marrow zinc finger 3) (bmzf-3). [swissprot;acc:q9y2p7]	Subtracted	Low confidence		382.97	2352.16	1969.19
111	brain protein 44. [swissprot;acc:o95563]			1	867.6	10392.1	11259.7
	melanoma antigen, family d, 4 isoform 1; mage1 protein; mage-e1 protein; maged4 protein. [refseq;acc:nm_030801]	Divided			1.0937	11285.3	10318.5
	protein arginine n-methyltransferase 4 (ec 2.1.1.-). [swissprot;acc:q9nr22]		High confidence		1.35116	4366.44	5899.76
	ribosomal protein s6 kinase-like 1. [refseq;acc:nm_031464]			0	1.43747	2965.5	2063
			Low confidence		1.37838	1763.83	1279.64
	succinate dehydrogenase [ubiquinone] flavoprotein subunit, mitochondrial precursor (ec 1.3.5.1) (fp) (flavoprotein subunit of complex ii). [swissprot;acc:p31040]	Subtracted	High confidence		287.2	10247.8	10535
	t-complex protein 1, gamma subunit (tcp-1-gamma) (cct-gamma). [swissprot;acc:p49368]			1	2459.7	12365.2	14824.9
	zinc finger protein 214 (bwscr2 associated zinc-finger protein 1) (baz 1). [swissprot;acc:q9ul59]		Low confidence	0	382.97	2352.16	1969.19
112	autophagy protein 12-like (apg12-like). [swissprot;acc:o94817]		High confidence	1	2405.69	11757.8	9352.11
	hepatocellular carcinoma-associated protein hca3. [refseq;acc:nm_138703]	Divided	Low confidence		1.0937	11285.3	10318.5
	lats homolog 1. [refseq;acc:nm_004690]		High confidence	0	1.42539	160	112.25
	monocarboxylate transporter 6 (mct 6) (mct 5). [swissprot;acc:o15375]	Subtracted	Low confidence	1	859	10351.8	11210.8
	probable calcium-transporting atpase kiaa0703 (ec 3.6.3.8). [swissprot;acc:o75185]		High confidence	0	283.254	1095.42	812.166
	transcription factor e2f2 (e2f-2). [swissprot;acc:q14209]	Divided	Low confidence		1.37602	1392.08	1011.67
	u1 small nuclear ribonucleoprotein 70 kda (u1 snrnp 70 kda) (snrnp70) (u1-70k). [swissprot;acc:p08621]		High confidence	1	1.35116	4366.44	5899.76
	zinc finger protein 165 (ld65). [swissprot;acc:p49910]	Subtracted	Low confidence	0	382.97	2352.16	1969.19
113	cyclic-amp-dependent transcription factor atf-3 (activating transcription factor 3). [swissprot;acc:p18847]		High confidence	1	2331.9	4800.81	7132.71
	filamin a (alpha-filamin) (filamin 1) (endothelial actin-binding protein) (abp-280) (nonmuscle filamin). [swissprot;acc:p21333]	Divided			1.35116	4366.44	5899.76
	melanoma-associated antigen 3 (mage-3 antigen) (antigen mz2-d). [swissprot;acc:p43357]		Low confidence		1.0937	11285.3	10318.5
	monocarboxylate transporter 1 (mct 1). [swissprot;acc:p53985]	Subtracted			858.2	10348.5	11206.7

Legend:
- Rank is the rank after comparing the two networks
- Gene is the ensembl human gene identifier measured by 1 or more probes on the microarray
- Value Type describes how the microarray measurement was processed. Ranked indicates that we sorted all measurements and use the rank as red and green value. Measured is the normal measurement. Squared and Rooted are the square and square root respecitcely. This might be valueable to compensate for non linear light distributions.
- Network Comparison Type describes whether we divided the red and green types or whether we sutractcted them
- Interaction Map specifies whether we used only the hig hconfidence protein-protein interactions or also included the low confidence interactions.
- Filtered specifies whether we only included the high confidence microarry measurements or not.