MK5 Microarray Data

These are the micro-array results of a differential gene expression microarray experiments and the subsequent analysis steps performed on them. The up/down- regulation ratio was obtained by measuring WT cells against MK5 activated cells. See material and methods for technical information as well as the data usage policy.

Affected Genes

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Ratio	Regulation	description	Gene Ontology	Class	Accession	Gene	Minimum Ratio	Maximum Ratio

Results: HTML CSV LaTeX

Showing element 818 to 867 of 2667 in total

Ratio	Regulation	description	Gene Ontology	Class
1.31661	up	Chloride anion exchanger (Protein DRA) (Down-regulated in adenoma) (Solute carrier family 26 member 3). [Uniprot/SWISSPROT;Acc:P40879]	chloride ion binding	molecular function
			cytochrome complex assembly	biological process
			excretion
			heme transport
			heme transporter activity	molecular function
			integral to membrane	cellular component
			membrane
			membrane fraction
			sulfate porter activity	molecular function
			sulfate transport	biological process
			transcription cofactor activity	molecular function
			transcription factor activity
			transport	biological process
			transporter activity	molecular function
1.31895		Fc receptor-like 1 [RefSeq_peptide;Acc:NP_443170]	receptor activity
1.32602	down	CDNA: FLJ22222 fis, clone HRC01658. [Uniprot/SPTREMBL;Acc:Q9H6J2]	oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, 2-oxoglutarate as one donor, and incorporation of one atom each of oxygen into both donors
			protein metabolic process	biological process
1.33329	up	Beta-mannosidase precursor (EC 3.2.1.25) (Lysosomal beta A mannosidase) (Mannanase) (Mannase). [Uniprot/SWISSPROT;Acc:O00462]	beta-mannosidase activity	molecular function
			carbohydrate metabolic process	biological process
			cation binding	molecular function
			glycoprotein catabolic process	biological process
			hydrolase activity, hydrolyzing O-glycosyl compounds	molecular function
			lysosome	cellular component
			metabolic process	biological process
			protein modification process
1.33465		T-box transcription factor TBX5 (T-box protein 5). [Uniprot/SWISSPROT;Acc:Q99593]	cell-cell signaling
			cytoplasm	cellular component
			embryonic arm morphogenesis	biological process
			embryonic limb morphogenesis
			forelimb morphogenesis
			heart development
			induction of apoptosis
			lung development
			morphogenesis of an epithelium
			multicellular organismal development
			negative regulation of cardiac muscle cell proliferation
			negative regulation of cell migration
			nucleus	cellular component
			pattern specification process	biological process
			pericardium development
			positive regulation of cardioblast differentiation
			positive regulation of transcription from RNA polymerase II promoter
			positive regulation of transcription, DNA-dependent
			protein binding	molecular function
			regulation of transcription, DNA-dependent	biological process
			RNA polymerase II transcription factor activity	molecular function
			sequence-specific DNA binding
			transcription	biological process
			transcription factor activity	molecular function
			transcriptional activator activity

Legend:
- The Ratio specifies how much this gene is up/down regulated. When up- or down-regulated must this value respectively be multiplied/divided to obtain the MK5 on concentration based on the MK5 off concentration.
- The Regulation specifies how this gene is affected when going from the MK5 off cells to the MK5 on cells.
- The Class refers to the ontology category, which can be molecular_function, biological_process or cellular_component.
- The Gene Ontology terms as linked to the specific gene.
- Gene is the ensembl human gene identifier measured by 1 or more probes on the microarray
- Accession is the GO accession key.
- Minimum Ratio is the lowest expected regulation ratio based on the replicate slides and a 95% symmetric confidence interval.
- Maximum Ratio is the highest expected regulation ratio based on the replicate slides and a 95% symmetric confidence interval.