MK5 Microarray Data

These are the micro-array results of a differential gene expression microarray experiments and the subsequent analysis steps performed on them. The up/down- regulation ratio was obtained by measuring WT cells against MK5 activated cells. See material and methods for technical information as well as the data usage policy.

Affected Genes

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Ratio	Regulation	description	Gene Ontology	Class	Gene	Accession	Minimum Ratio	Maximum Ratio

Results: HTML CSV LaTeX

Showing element 1818 to 1867 of 2667 in total

Ratio	Regulation	description	Gene Ontology	Class
2.2866	up	Protein phosphatase 1A (EC 3.1.3.16) (Protein phosphatase 2C isoform alpha) (PP2C-alpha) (IA). [Uniprot/SWISSPROT;Acc:P35813]	protein phosphatase type 2C activity	molecular function
			protein serine/threonine phosphatase activity
			protein serine/threonine phosphatase complex	cellular component
			signal transducer activity	molecular function
			voltage-gated calcium channel complex	cellular component
2.29381		Ataxin-7 (Spinocerebellar ataxia type 7 protein). [Uniprot/SWISSPROT;Acc:O15265]	cell death	biological process
			chromatin binding	molecular function
			cytoplasm	cellular component
			intracellular
			nuclear organization and biogenesis	biological process
			nucleus	cellular component
			protein binding	molecular function
			visual perception	biological process
			zinc ion binding	molecular function
2.2939		Hermansky-Pudlak syndrome 3 protein. [Uniprot/SWISSPROT;Acc:Q969F9]	cytoplasm	cellular component
			organelle organization and biogenesis	biological process
			pigmentation
2.31039		STAGA complex 65 subunit gamma (STAF65gamma) (SPTF-associated factor 65 gamma) (Suppressor of Ty 7-like) (Adenocarcinoma antigen ART1). [Uniprot/SWISSPROT;Acc:O94864]	maintenance of protein localization in nucleus
			nucleus	cellular component
			protein binding	molecular function
			regulation of transcription, DNA-dependent	biological process
			transcription
2.31699	down	Serine/threonine-protein phosphatase 2A catalytic subunit beta isoform (EC 3.1.3.16) (PP2A-beta). [Uniprot/SWISSPROT;Acc:P62714]	cytoplasm	cellular component
			hydrolase activity	molecular function
			iron ion binding
			manganese ion binding
			metal ion binding
			phosphoprotein phosphatase activity
			protein amino acid dephosphorylation	biological process
			protein binding	molecular function
			protein phosphatase type 2A activity
			protein phosphatase type 2A complex	cellular component
2.33107		F-box only protein 15. [Uniprot/SWISSPROT;Acc:Q8NCQ5]	protein binding	molecular function
			SCF ubiquitin ligase complex	cellular component
			ubiquitin cycle	biological process
2.37788	up	Coiled-coil domain-containing protein 83. [Uniprot/SWISSPROT;Acc:Q8IWF9]	structural molecule activity	molecular function
			viral capsid	cellular component
2.43098		Oxysterol-binding protein-related protein 2 (OSBP-related protein 2) (ORP-2). [Uniprot/SWISSPROT;Acc:Q9H1P3]	lipid transport	biological process
			steroid metabolic process
2.44552	down	Guanine nucleotide-binding protein alpha-14 subunit (G-protein alpha subunit 14). [Uniprot/SWISSPROT;Acc:O95837]	G-protein coupled receptor protein signaling pathway
			GTP binding	molecular function
			GTPase activity
			guanyl nucleotide binding
			heterotrimeric G-protein complex	cellular component
			nucleotide binding	molecular function
			plasma membrane	cellular component
			protein amino acid ADP-ribosylation	biological process
			signal transducer activity	molecular function
			signal transduction	biological process
2.45383		40S ribosomal protein S2 (S4) (LLRep3 protein). [Uniprot/SWISSPROT;Acc:P15880]	cytosolic small ribosomal subunit (sensu Eukaryota)	cellular component

Legend:
- The Ratio specifies how much this gene is up/down regulated. When up- or down-regulated must this value respectively be multiplied/divided to obtain the MK5 on concentration based on the MK5 off concentration.
- The Regulation specifies how this gene is affected when going from the MK5 off cells to the MK5 on cells.
- The Class refers to the ontology category, which can be molecular_function, biological_process or cellular_component.
- The Gene Ontology terms as linked to the specific gene.
- Gene is the ensembl human gene identifier measured by 1 or more probes on the microarray
- Accession is the GO accession key.
- Minimum Ratio is the lowest expected regulation ratio based on the replicate slides and a 95% symmetric confidence interval.
- Maximum Ratio is the highest expected regulation ratio based on the replicate slides and a 95% symmetric confidence interval.