MK5 Microarray Data

These are the micro-array results of a differential gene expression microarray experiments and the subsequent analysis steps performed on them. The up/down- regulation ratio was obtained by measuring WT cells against MK5 activated cells. See material and methods for technical information as well as the data usage policy.

Affected Genes

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Ratio	Regulation	description	Class	Gene Ontology	Gene	Accession	Minimum Ratio	Maximum Ratio

Results: HTML CSV LaTeX

Showing element 1768 to 1817 of 2667 in total

Ratio	Regulation	description	Class	Gene Ontology
2.12709	down	Ribonuclease P protein subunit p29 (EC 3.1.26.5) (hPOP4). [Uniprot/SWISSPROT;Acc:O95707]	cellular component	ribonuclease MRP complex
				ribonuclease P complex
			molecular function	hydrolase activity
				identical protein binding
				ribonuclease activity
				ribonuclease P activity
				RNA binding
2.16131		39S ribosomal protein L15, mitochondrial precursor (L15mt) (MRP-L15). [Uniprot/SWISSPROT;Acc:Q9P015]	biological process	translation
			cellular component	intracellular
				large ribosomal subunit
				mitochondrion
				ribosome
			molecular function	structural constituent of ribosome
2.20843	up	Proto-oncogene tyrosine-protein kinase Yes (EC 2.7.10.2) (p61-Yes) (c- Yes). [Uniprot/SWISSPROT;Acc:P07947]	biological process	glucose transport
				intracellular signaling cascade
				protein amino acid autophosphorylation
				protein amino acid phosphorylation
				protein modification process
			cellular component	cytoplasm
				membrane fraction
			molecular function	ATP binding
				nucleotide binding
				protein binding
				protein kinase activity
				protein serine/threonine kinase activity
				protein-tyrosine kinase activity
				transferase activity
2.25955	down	Threonyl-tRNA synthetase, mitochondrial precursor (EC 6.1.1.3) (Threonine--tRNA ligase) (ThrRS) (Threonyl-tRNA synthetase-like 1). [Uniprot/SWISSPROT;Acc:Q9BW92]	biological process	threonyl-tRNA aminoacylation
				translation
				tRNA aminoacylation for protein translation
			cellular component	cytoplasm
				mitochondrion
			molecular function	aminoacyl-tRNA ligase activity
				ATP binding
				ligase activity
				nucleotide binding
				threonine-tRNA ligase activity
2.27115		RIM-binding protein 2 (RIM-BP2). [Uniprot/SWISSPROT;Acc:O15034]	cellular component	cell junction
				membrane
				synapse
2.2866	up	Protein phosphatase 1A (EC 3.1.3.16) (Protein phosphatase 2C isoform alpha) (PP2C-alpha) (IA). [Uniprot/SWISSPROT;Acc:P35813]	biological process	positive regulation of I-kappaB kinase/NF-kappaB cascade
				protein amino acid dephosphorylation
			cellular component	membrane fraction
				neuron projection
				protein serine/threonine phosphatase complex
				voltage-gated calcium channel complex
			molecular function	catalytic activity
				hydrolase activity
				magnesium ion binding
				manganese ion binding

Legend:
- The Ratio specifies how much this gene is up/down regulated. When up- or down-regulated must this value respectively be multiplied/divided to obtain the MK5 on concentration based on the MK5 off concentration.
- The Regulation specifies how this gene is affected when going from the MK5 off cells to the MK5 on cells.
- The Class refers to the ontology category, which can be molecular_function, biological_process or cellular_component.
- The Gene Ontology terms as linked to the specific gene.
- Gene is the ensembl human gene identifier measured by 1 or more probes on the microarray
- Accession is the GO accession key.
- Minimum Ratio is the lowest expected regulation ratio based on the replicate slides and a 95% symmetric confidence interval.
- Maximum Ratio is the highest expected regulation ratio based on the replicate slides and a 95% symmetric confidence interval.