MK5 Microarray Data

These are the micro-array results of a differential gene expression microarray experiments and the subsequent analysis steps performed on them. The up/down- regulation ratio was obtained by measuring WT cells against MK5 activated cells. See material and methods for technical information as well as the data usage policy.

Affected Genes

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Ratio	Regulation	description	Gene Ontology	Class	Gene	Accession	Minimum Ratio	Maximum Ratio

Results: HTML CSV LaTeX

Showing element 418 to 467 of 2667 in total

Ratio	Regulation	description	Gene Ontology	Class
1.21871	down	Bcl-2-interacting killer (Apoptosis inducer NBK) (BP4) (BIP1). [Uniprot/SWISSPROT;Acc:Q13323]	apoptotic program	biological process
			induction of apoptosis
			integral to membrane	cellular component
			membrane
			mitochondrial envelope
			protein binding	molecular function
			regulation of apoptosis	biological process
1.22047	up	HORMA domain-containing protein 1 (Newborn ovary HORMA protein) (Cancer/testis antigen CT46). [Uniprot/SWISSPROT;Acc:Q86X24]	mitosis
			nucleus	cellular component
1.22178		Serine/threonine-protein kinase PFTAIRE-1 (EC 2.7.11.22). [Uniprot/SWISSPROT;Acc:O94921]	ATP binding	molecular function
			cytoplasm	cellular component
			cytosol
			heme binding	molecular function
			nucleotide binding
			nucleus	cellular component
			protein amino acid phosphorylation	biological process
			protein binding	molecular function
			protein kinase activity
			protein serine/threonine kinase activity
			protein-tyrosine kinase activity
			transferase activity
			transition metal ion binding
1.22502		ATP-binding cassette sub-family A member 3 (ATP-binding cassette transporter 3) (ATP-binding cassette 3) (ABC-C transporter). [Uniprot/SWISSPROT;Acc:Q99758]	ATP binding
			ATPase activity
			ATPase activity, coupled to transmembrane movement of substances
			integral to membrane	cellular component
			lamellar body
			membrane fraction
			nucleoside-triphosphatase activity	molecular function
			nucleotide binding
			plasma membrane	cellular component
			response to drug	biological process
			transport
			transporter activity	molecular function
1.22528		protein tyrosine phosphatase domain containing 1 protein isoform 2 [RefSeq_peptide;Acc:NP_818931]	dephosphorylation	biological process
			hydrolase activity	molecular function
			phosphoric monoester hydrolase activity
			protein amino acid dephosphorylation	biological process
			protein tyrosine phosphatase activity	molecular function
			protein tyrosine/serine/threonine phosphatase activity
1.22576		Methyl-CpG-binding domain protein 1 (Methyl-CpG-binding protein MBD1) (Protein containing methyl-CpG-binding domain 1). [Uniprot/SWISSPROT;Acc:Q9UIS9]	DNA binding
			metal ion binding
			methyl-CpG binding
			negative regulation of transcription	biological process
			nucleus	cellular component
			protein binding	molecular function
			regulation of transcription, DNA-dependent	biological process
			transcription
			transcription corepressor activity	molecular function
			transcription factor activity

Legend:
- The Ratio specifies how much this gene is up/down regulated. When up- or down-regulated must this value respectively be multiplied/divided to obtain the MK5 on concentration based on the MK5 off concentration.
- The Regulation specifies how this gene is affected when going from the MK5 off cells to the MK5 on cells.
- The Class refers to the ontology category, which can be molecular_function, biological_process or cellular_component.
- The Gene Ontology terms as linked to the specific gene.
- Gene is the ensembl human gene identifier measured by 1 or more probes on the microarray
- Accession is the GO accession key.
- Minimum Ratio is the lowest expected regulation ratio based on the replicate slides and a 95% symmetric confidence interval.
- Maximum Ratio is the highest expected regulation ratio based on the replicate slides and a 95% symmetric confidence interval.